A motivating example
Imagine a mortgage book with $100mm$ of current market value and an effective duration of $5.0$ years. A simple first pass says the price sensitivity to a small rate change is roughly
If rates move up by $100$ basis points, the linear approximation would suggest about a $5\%$ price hit before we even worry about convexity. The catch is that MBS do not keep the same duration when rates move.
In a lower-rate world, borrowers refinance faster, prepayments speed up, and duration shortens. When rates rise, the opposite happens: prepayment incentive fades, expected life extends, and the position can become much more rate-sensitive than the hedge that was put on yesterday.